{"id":7037,"date":"2017-02-14T09:47:48","date_gmt":"2017-02-14T09:47:48","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=7037"},"modified":"2017-02-14T09:47:48","modified_gmt":"2017-02-14T09:47:48","slug":"huntingtons-disease-linked-to-dysfunction-of-brain-structure","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/pt-pt\/2017\/02\/huntingtons-disease-linked-to-dysfunction-of-brain-structure\/","title":{"rendered":"Huntington’s disease linked to dysfunction of brain structure"},"content":{"rendered":"

Researchers have identified a link between Huntington’s disease and dysfunction of the subthalamic nucleus, a component of the basal ganglia, a group of brain structures critical for movement and impulse control.<\/p>\n

Huntington’s disease is characterized by the progressive loss of nerve cells in the brain and affects approximately 1 in 10,000 people. This fatal disorder is caused by a hereditary defect in a single gene.<\/p>\n

The study was published in the journal eLife<\/em>.<\/p>\n

Using mice genetically engineered to carry the Huntington’s disease gene, scientists discovered the electrical activity of the subthalamic nucleus was lost. Furthermore, impaired subthalamic activity was caused by anomalous receptor signaling, leading to defective energy metabolism and accumulation of damaging oxidants. The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington’s disease.<\/p>\n

Currently, there is no cure for Huntington’s disease; treatment can only alleviate some of the symptoms. A better understanding of aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target for therapy, according to the authors.<\/p>\n

Paper: \u201cEarly dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington’s disease\u201d<\/a><\/strong>
\n Reprinted from materials provided by Northwestern Medicine<\/a>.<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers have identified a link between Huntington’s disease and dysfunction […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-7037","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nHuntington's disease linked to dysfunction of brain structure - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/02\/huntingtons-disease-linked-to-dysfunction-of-brain-structure\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Huntington's disease linked to dysfunction of brain structure - 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