{"id":8091,"date":"2017-05-09T07:50:59","date_gmt":"2017-05-09T07:50:59","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=8091\/"},"modified":"2017-05-09T07:50:59","modified_gmt":"2017-05-09T07:50:59","slug":"sugars-tipping-point-link-to-alzheimers-disease-revealed","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/pt-pt\/2017\/05\/sugars-tipping-point-link-to-alzheimers-disease-revealed\/","title":{"rendered":"Sugar\u2019s \u201ctipping point\u201d link to Alzheimer\u2019s disease revealed"},"content":{"rendered":"

For the first time a \u201ctipping point\u201d molecular link between the blood sugar glucose and Alzheimer\u2019s disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer\u2019s.<\/p>\n

The study was published in Scientific Reports<\/em>.<\/p>\n

Abnormally high blood sugar levels, or hyperglycaemia, is well-known as a characteristic of diabetes and obesity, but its link to Alzheimer\u2019s disease is less familiar.
\nDiabetes patients have an increased risk of developing Alzheimer\u2019s disease compared to healthy individuals. In Alzheimer\u2019s disease abnormal proteins aggregate to form plaques and tangles in the brain which progressively damage the brain and lead to severe cognitive decline.<\/p>\n

Scientists already knew that glucose and its break-down products can damage proteins in cells via a reaction called glycation but the specific molecular link between glucose and Alzheimer\u2019s was not understood.<\/p>\n

But now scientists have unraveled that link. By studying brain samples from people with and without Alzheimer\u2019s using a sensitive technique to detect glycation, the team discovered that in the early stages of Alzheimer\u2019s glycation damages an enzyme called MIF (macrophage migration inhibitory factor) which plays a role in immune response and insulin regulation.<\/p>\n

MIF is involved in the response of brain cells called glia to the build-up of abnormal proteins in the brain during Alzheimer\u2019s disease, and the researchers believe that inhibition and reduction of MIF activity caused by glycation could be the \u2018tipping point\u2019 in disease progression. It appears that as Alzheimer\u2019s progresses, glycation of these enzymes increases.<\/p>\n

Paper: \u201cMacrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer\u2019s Disease\u201d<\/a><\/strong>
\n Reprinted from materials provided by University of Bath.<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

For the first time a \u201ctipping point\u201d molecular link between […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4991,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-8091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nSugar\u2019s \u201ctipping point\u201d link to Alzheimer\u2019s disease revealed - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/05\/sugars-tipping-point-link-to-alzheimers-disease-revealed\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sugar\u2019s \u201ctipping point\u201d link to Alzheimer\u2019s disease revealed - 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