ROSA26-hsynE46K(1-119) – Mouse

General Information

Mouse: CB576J x 129/SvJ

Conditional expression of the human C-terminally truncated (1-119) E46K mutant alpha-synuclein protein under the control of the endogenous ROSA 26 promoter in a Cre recombinase -dependent manner. Breeding with TH-Cre transgenic mice allows selective expression of the transgene in dopaminergic neurons.

Endogenous mouse alpha synuclein: Yes.

Corresponding human genotype: E46K mutation is responsible for a rare autosomal dominant familial form of PD. Truncated forms of alpha-synuclein are detected in brain tissue from post mortem PD brain and are enriched in Lewy bodies

Transgene insertion:  ROSA 26 locus

References: Daher 2009

Transgene expression

  • Not reported

Neurodegeneration

  • Not reported

Dopamine Homeostasis

  • Not reported

Inclusions

  • Not reported

Motor Behaviours

  • Not reported

Response to L-DOPA treatment

  • Not reported

Non motor Behaviours

  • Not reported

Electrophysiology

  • Not reported

Neuroinflammation

  • Not reported
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