Shanghai Cohort Study on Mild Cognitive Impairment

The study is a prospective cohort study that included 400 subjects with MCI enrolled in at Huashan Hospital in Shanghai, China and a followed-up once annually for three years. The objectives are to identify individuals with MCI who convert to AD and to explore factors associated with the conversion. The observation time point is every 12 months and phone interview on 6th, 18th month. The primary endpoint was the time from diagnosis to the conversion from MCI to Probable AD Dementia. The secondary endpoints are the time to conversion from MCI to “Possible AD Dementia” or “Probable AD Dementia”, time to Conversion from MCI to “All-cause Dementia”, Overall survival, Changes in Neuropsychological examinations and Changes in MRI from baseline to the end of follow-up. The planned research duration was from Jan 2012 to Dec 2016.

Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries China|Japan
Genders Male and Female
Sample sizes 0 to 4,999
Ages 40 to 59|60 to 100
Brain related measures
Funtional rating Individual physiological|Individual psychological
Anthropometric Height|Weight
Physical Cardiovascular|Hearing and Vision
Biological samples Blood
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)
Brain banking
Lifestyle Alcohol|Physical activity|Smoking
Socio-economic Education|Martial status
Health service utilisation Formal health and social care service utilisation including private care
Institute names Foundation for Biomedical Research and Innovation|Fudan University
Current Sample Sizes 0 to 4,999

age at recruitment >18
last updated
recruitment period 2012-2014
estimated current sample size number value
cohort acronym
start date 2012-2014
pi Professor Bin Zhou
website http://www.omicsonline.org/open-access/shanghai-cohort-study-on-mild-cognitive-impairment-study-desig-nand-baseline-characteristics-2161-0460-1000224.php?aid=72294
contact details Bin Zhou
Translational Research Informatics Center
Foundation for Biomedical Research and Innovation
1-5-4 Minatojimaminamimachi, Chuo-ku, Kobe, Japan 650-0047
abstract  Establish cohort of patients with mild cognitive impairment (MCI) in order to identify the risk factors and validation of neuropsychological tests for early detection of Alzheimer disease.
funders  The Foundation of Biomedical Research and Innovation
contact email [email protected]
contact phone number -3039090
estimated current sample size
sample sizes 400