Principal Investigators

    J. Schwamborn, H.Schöler, P.Ertl, V.Bonifati, D.Seliktar



    Contact information of lead PI



    Title of project or programme

    3DPD: Advanced modelling of Parkinson’s disease with three-dimensional human midbrain organoids

    Source of funding information


    Total sum awarded (Euro)

    € 1,487,850

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    One of the main limitations in neuroscience and in the modeling of neurodegenerative diseases is the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Therefore, it is the aim of this research project to generate brain-like structures, so called organoids, that resemble the human midbrain. These organoids will be developed in a multifunctional lab-on-a-chip device. We call this a midbrain-on-a-chip approach. We will focus on Parkinson’s disease, which is the second most common neurodegenerative dis- ease. The midbrains-on-a-chip will be generated from induced pluripotent stem cells derived from Parkinson’s disease patients. This will allow us to elucidate how Parkinson’s disease imparts architectural remodelling, dopamine release and network formation of the midbrain tissue. The successful cultivation of in vitro midbrain organoids in a micro-analytical analysis platform will yield substantial insights and open new avenues for exploring the mechanisms of onset and pro- gression under physiologically relevant measurement conditions. Moreover, with the usage of mi- crofluidics devices, the whole approach is cost-effective and suitable for screening purposes.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Austria, Germany, Israel, JPND, Luxembourg, Netherlands
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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