Principal Investigators


Bedell, Barry J

Institution


McGill University

Contact information of lead PI


Country


Canada

Title of project or programme


Cerebrovascular pathophysiology in mouse models of Alzheimer's disease

Source of funding information


CIHR

Total sum awarded (Euro)


€ 406,583

Start date of award


01/04/2012

Total duration of award in years


4

Keywords


Research Abstract


Abnormal function of the blood vessels in the brain has been identified as a potential factor in the development and/or progression of Alzheimer’s disease (AD). Our group has previously identified reduced blood flow in mouse models of AD using specialized magnetic resonance imaging (MRI) techniques. This technique primarily examined blood flow in the smaller brain vessels, called capillaries. In this proposed project, we seek to evaluate the function of larger vessels, called arteries and arterioles. These larger vessels are known to accumulate abnormal amounts of a protein, called beta-amyloid, in AD patients and in mouse models of AD. This approach may provide an early indicator of the risk for the development and progression of AD.

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