Principal Investigators

    Jerome Swinny


    University of Portsmouth

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Characterisation of enteric nervous system function of the intestine in Alzheimer’s disease

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 63,740

    Start date of award


    Total duration of award in years



    Research Abstract

    Alzheimer’s disease (AD) results in the death of neurons within the brain which severely impairs cognition, mood and behaviour. AD patients also present with symptoms arising from other body systems such as the gastrointestinal (GI) system. Together, these central and peripheral symptoms impose an immense burden not only to AD patients but to their caregivers. Whilst GI disorders are not the primary cause of death in AD, identifying the underlying disease mechanisms will help to design targeted therapeutic strategies which will improve the quality of life of patients. Virtually all aspects of GI function are regulated by a local nervous system, called the enteric nervous system (ENS). Our pilot data in a mouse model of AD indicate significant changes in the expression of molecules within the ENS of the intestine which are likely to alter ENS, and thus GI function in AD. The aim of the project is to characterise these AD-associated changes in the ENS of the intestine and determine how these changes impact on GI function. This will lead to the development of treatment for an aspect of the disease which imparts an immense negative influence on the quality of life of patients.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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