Principal Investigators

    Huttunen Henri


    University of Helsinki

    Contact information of lead PI



    Title of project or programme

    Coupling factor 6, a circulating vasoactive peptide, in Alzheimer’s disease

    Source of funding information

    Academy of Finland

    Total sum awarded (Euro)

    € 528,919

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias|Neurodegenerative disease in general


    Research Abstract

    The most common form of dementia, late-onset Alzheimer’s disease (AD), is strongly associated with cardiovascular and metabolic factors, such as hypertension, hypercholesterolemia and type 2 diabetes. On a molecular level, how cardiovascular and metabolic factors contribute to development of neurodegeneration is still poorly understood. We have identified a potential molecular factor linking the cardiovascular and neuronal aspects of AD pathobiology. Here, we propose a comprehensive study combining in vitro, animal and human sample studies to address the role of the vasoactive peptide CF6 as a modulator of neuronal physiology and risk factor of AD. This study will provide novel mechanistic insight how cardiovascular factors are linked to neurodegeneration on a molecular level. The results of the proposed work are expected to pave new ways for diagnosis and treatment of late-life dementia, which is increasingly associated with cardiovascular and metabolic diseases.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Finland
Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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