Principal Investigators


Huttunen Henri

Institution


University of Helsinki

Contact information of lead PI


Country


Finland

Title of project or programme


Coupling factor 6, a circulating vasoactive peptide, in Alzheimer’s disease

Source of funding information


Academy of Finland

Total sum awarded (Euro)


€ 528,919

Start date of award


01/09/2016

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias|Neurodegenerative disease in general

Keywords


Research Abstract


The most common form of dementia, late-onset Alzheimer’s disease (AD), is strongly associated with cardiovascular and metabolic factors, such as hypertension, hypercholesterolemia and type 2 diabetes. On a molecular level, how cardiovascular and metabolic factors contribute to development of neurodegeneration is still poorly understood. We have identified a potential molecular factor linking the cardiovascular and neuronal aspects of AD pathobiology. Here, we propose a comprehensive study combining in vitro, animal and human sample studies to address the role of the vasoactive peptide CF6 as a modulator of neuronal physiology and risk factor of AD. This study will provide novel mechanistic insight how cardiovascular factors are linked to neurodegeneration on a molecular level. The results of the proposed work are expected to pave new ways for diagnosis and treatment of late-life dementia, which is increasingly associated with cardiovascular and metabolic diseases.

Lay Summary


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