Principal Investigators

    T.Gasser, A.Elbaz, S.Goldwurm, M.Toft, N.Wood, A.Orr-Urteger, J.Ferreira, E.Tolosa, R.Balling, P.Heutink/JJ. Van Hilten



    Contact information of lead PI


    Germany|France|Italy|Norway|United Kingdom|Israel|Spain|Luxembourg|Netherlands

    Title of project or programme

    COURAGE-PD: COmprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson‘s Disease

    Source of funding information

    JPND-Risk Factors

    Total sum awarded (Euro)

    € 4,593,189

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Despite years of research and the considerable progress that has been achieved by identifying a number of genes and genetic risk factors for Parkinson’s disease (PD), the cause for vast majority of cases is still unknown. It is suspected that a multitude of interacting genetic and environmental risk factors, rather than single genetic mutations or single toxins, are responsible for the disease in most instances. The project “COmprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson‘s Disease (Courage-PD)” takes an integrated approach to unravel these underlying factors. The genetic make- up of large, well-characterized patient cohorts from different ethnic populations will be deciphered. At the same time, environmental exposures will be documented, and interactions between both classes of risk factors will be elucidated using novel statistical methods. Finally, the relevance and validity of the findings will be tested in innovative cellular models, including neuronal cells, which will be generated from patient-derived induced pluripotent stem cells. We expect that this combination of state-of-the-art genetic technologies with a detailed ascertainment of environmental modifiers will provide important clues to decipher the complexity of neurodegeneration in Parkinson’s Disease

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: France, Germany, Israel, Italy, JPND, Luxembourg, Netherlands, Norway, Spain, United Kingdom
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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