Principal Investigators

    G.Petzold, M.Nedergaard, M.Heneka, C.Göritz, S.Oliet



    Contact information of lead PI



    Title of project or programme

    DACAPO-AD: Deciphering Interactions of Acquired Risk Factors and ApoE-mediated Pathways in Alzheimer’s Disease

    Source of funding information


    Total sum awarded (Euro)

    € 1,594,408

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Alzheimer’s disease (AD) imposes an enormous personal burden on patients and caregivers, as well as a tremendous socio-economic impact on society. However, there is a paucity of pharmaceutical or interventional strategies that have a proven impact on the incidence or progression of AD. One reason is that most models are based on familial (early-onset) AD pathogenesis, but typically do not reflect the multifactorial pathophysiology of sporadic (late-onset) AD, which is associated with genetic risk factors such as the apolipoprotein E (ApoE) ?4 polymorphism, as well as environmental risk factors, such as a high-fat diet, cardiovascular disease, traumatic brain inju- ry, systemic inflammation and perturbed sleep regulation. We aim to create novel AD models that combine the most common genetic risk factor (ApoE-?4) and many of the most prevalent acquired risk factors, enabling us to better understand the multi- factorial and highly prevalent, yet currently understudied, interplay between inherited and acquired risk factors in the pathophysiology of late-onset AD. These models may therefore be more predictive of possible translatability into clinical studies, and may potentially lead to the develop- ment of new avenues of primary prevention or treatment.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Denmark, France, Germany, JPND, Sweden
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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