Principal Investigators


Salminen Outi

Institution


University of Helsinki

Contact information of lead PI


Country


Finland

Title of project or programme


Distinct nicotinic acetylcholine receptors in dorsal and ventral striatum: Basis for novel therapies of Parkinson's disease

Source of funding information


Academy of Finland

Total sum awarded (Euro)


€ 433,299

Start date of award


01/09/2013

Total duration of award in years


4

Keywords


Research Abstract


Parkinson´s disease is levodopa. However, levodopa treatment is plagued by adverse effects, especially dyskinesias that affect the whole body. Presently, there is no effective drug therapy against dyskinesias. In animal models, it has been shown that nicotinic drugs could be effective in treating dyskinesias. This study aims at clarifying what are the mechanisms of levodopa-induced dyskinesias and, further, how nicotine elicits its antidyskinetic effect. The aim of the proposed research is to build the basis for development of improved drug therapy for currently poorly treated aspects of Parkinson´s disease.

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