Name of Fellow

    Dr Jill Fowler



    Alzheimer's Society

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Do inflammatory mechanisms cause Alzheimer’s disease following brain injury?

    Source of funding information

    Alzheimer's Society

    Total sum awarded (Euro)

    € 252,096

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Traumatic brain injury (TBI) is proposed to play a critical role in the development of
    Alzheimer’s Disease. We have established in vivo models of brain injury that cause cognitive
    deficits and accelerate amyloid pathology. This project will build on this work to elucidate the
    mechanisms by which brain injury can lead to Alzheimer’s Disease. The following hypothesis
    will be tested: Chronic inflammation caused by mild TBI leads to amyloid and tau pathology
    and cognitive deficits.
    We will address this hypothesis by studying the effects of mild TBI in mouse models of
    Alzheimer’s disease and human post mortem tissue. We will exploit emerging, innovative
    proteomic technology to identify key protein changes following brain injury. The following
    aims will be investigated:
    (1) To identify the key proteins and signalling pathways involved in inflammation in
    human brain injury and following in vivo brain injury in AD mouse models.
    (2) To determine if a novel, multi-functional anti-inflammatory and anti-oxidant treatment
    can attenuate amyloid and tau pathology and cognitive decline following brain injury
    in AD mouse models

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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