Principal Investigators

    JC. Lambert, A.Ramirez, M.Hiltunen, G.Rossi, W. Van der Flier, M.Ingelsson, R.Sims, F.Jessen, K.Mather



    Contact information of lead PI


    France|Germany|Finland|Italy|Netherlands|Sweden|United Kingdom|Australia

    Title of project or programme

    EADB: A European DNA bank for deciphering the missing heritability of Alzheimer’s disease

    Source of funding information


    Total sum awarded (Euro)

    € 3,644,713

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Understanding the genetics of Alzheimer’s disease (AD) is one of the best ways of improving our knowledge of the disease’s underlying pathophysiological processes. Indeed, genetic factors account for up to 70% of the attributable risk in common forms of AD. The advent of genomic approaches has led to the characterization of 26 genetic determinants. However, it has been estimated that less than 50% of the AD genetic attributable risk has been cha- racterised. Substantial additional efforts are thus still needed to explore the AD genetic landscape. However, exhaustively characterising the genetic factors of AD will require analysing large populations of cases and controls. Our objective is thus to significantly increase the genera- tion of genetic data via the creation of a European Alzheimer’s Disease DNA BioBank (EADB). Our project will collate 31,911 AD cases and 40,802 controls from 11 countries. This initiative will increase the number of AD samples available for genetic studies in Europe by more than 4-fold and worldwide by almost 2-fold. In parallel, the EADB will collect DNA samples from Europe’s largest longitudinal cohort of cases suffering from mild cognitive impairment (9,109 cases), with a view to identifying ge- netic markers that modulate the rate of disease progression and cognitive decline.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Australia, Finland, France, Germany, Italy, JPND, Netherlands, Sweden, United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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