Principal Investigators


Prof Anthony Hannan

Institution


University of Melbourne

Contact information of lead PI


Country


Australia

Title of project or programme


Gene-environment interactions modulating cognition and dementia in Huntington’s disease

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 263,032

Start date of award


01/01/2015

Total duration of award in years


3

Keywords


Research Abstract


We are investigating mechanisms whereby cognitive symptoms, culminating in dementia, occur in a fatal brain disease, Huntington’s. We will explore how the ‘genetic stutter’ affects the brain at the level of molecules and cells, which will help identify targets for future treatment. We will also establish how environmental factors, including cognitive stimulation, physical activity and stress, modulate dementia. This will inform the development of treatments for this currently incurable disease.

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