Principal Investigators

    Dr John Boyle


    University of Leeds

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Hydrogen sulphide-mediated sulfhydration of the K+ channel Kv2.1: A new signalling pathway to target in the treatment of Alzheimer’s disease.

    Source of funding information

    Alzheimer's Society

    Total sum awarded (Euro)

    € 313,708

    Start date of award


    Total duration of award in years



    Research Abstract

    Oxidative damage of lipids and proteins is a hallmark feature of the early stages of Alzheimer’s disease (AD). One key protein known to undergo oxidation is the K+ channel Kv2.1, resulting in increased vulnerability to apoptosis. We have discovered that hydrogen sulfide (H2S), now accepted as a biological signalling molecule of widespread importance, directly modulates Kv2.1 activity and protects against apoptosis. In this study, we will establish the neuroprotective effects of H2S – acting via modulation of Kv2.1 – against the oxidative stress of AD. Our results will determine whether H2S has potential as a novel therapeutic approach to the treatment of AD, as it is for several other disorders.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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