Principal Investigators


Dr John Boyle

Institution


University of Leeds

Contact information of lead PI


Country


United Kingdom

Title of project or programme


Hydrogen sulphide-mediated sulfhydration of the K+ channel Kv2.1: A new signalling pathway to target in the treatment of Alzheimer’s disease.

Source of funding information


Alzheimer's Society

Total sum awarded (Euro)


€ 313,708

Start date of award


01/09/2014

Total duration of award in years


3

Keywords


Research Abstract


Oxidative damage of lipids and proteins is a hallmark feature of the early stages of Alzheimer’s disease (AD). One key protein known to undergo oxidation is the K+ channel Kv2.1, resulting in increased vulnerability to apoptosis. We have discovered that hydrogen sulfide (H2S), now accepted as a biological signalling molecule of widespread importance, directly modulates Kv2.1 activity and protects against apoptosis. In this study, we will establish the neuroprotective effects of H2S – acting via modulation of Kv2.1 – against the oxidative stress of AD. Our results will determine whether H2S has potential as a novel therapeutic approach to the treatment of AD, as it is for several other disorders.

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