Principal Investigators

    B.Dermaut, MC Galas, T.Voet, B. De Strooper, V.Bohr, J.Lundeberg



    Contact information of lead PI


    France|United Kingdom|Belgium|Denmark|Sweden

    Title of project or programme

    INSTALZ: Genomic Instability in Alzheimer’s Disease and Related Disorders: a Single-Cell Approach

    Source of funding information


    Total sum awarded (Euro)

    € 1,837,608

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Increasing evidence suggests that the genetic information in our bodies can vary from cell to cell. Such variation has also been found in the brain, although its consequences for brain function or disease remain largely unknown. In this project, we will study the role of genomic instability in Alzheimer’s disease and related tauopathies. The INSTALZ consortium aims to understand how altered stability of the neuronal genome in the developing and adult brain determines the risk of developing these chro- nic disorders in late adulthood. In particular, we will investigate how and when during life this cell-to-cell genomic variation could be generated by applying single-cell sequencing of neurons derived from patient brains and several mouse and fly models. The expected im- pact is to genetically explain the pathogenesis of a consistent part of sporadic cases, for which no pathogenic cause is yet known and to discover the underlying molecular me- chanisms that will lead to new early therapeutic tools.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Belgium, Denmark, France, JPND, Sweden, United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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