Principal Investigators

    Prof Brett Garner


    University of Wollongong

    Contact information of lead PI



    Title of project or programme

    Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer’s disease risk.

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 286,639

    Start date of award


    Total duration of award in years



    Research Abstract

    We recently discovered that a protein called apoE is cleaved in the brain to generate a small fragment that may have neuroprotective properties. We also discovered that human induced pluripotent stem cell (iPSC)-derived neurons produce apoE fragments identical to those in the brain. We will now characterise iPSC apoE and assess its neuroprotective properties. This will resolve the basis for the association of apoE with AD risk and potentially provide a new target for AD treatment.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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