Principal Investigators

    Clemens Kaminski


    University of Cambridge

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Live cell tracking of amyloidogenic species related to Alzheimer’s disease

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 380,854

    Start date of award


    Total duration of award in years



    Research Abstract

    In our group, we have recently developed a new kind of microscope, a so called optical super-resolution microscope, which is so powerful that it is capable of visualising the shape of amyloid protein aggregates directly in cultured brain cells, which we use as model systems of disease. We were the first researchers to demonstrate that it is possible to obtain ‘images’ of toxic protein shapes in neurones, and here we propose to use this newly developed tool to shed new light on the mechanisms that lead to the onset and propagation of neurodegenerative diseases.

    The aims of our proposed research project are: 1) to identify specific species of A? and tau in neurones and other cells present in the brain and to relate the shape, and size of these species to the appearance of disease symptoms. 2) to study A? and tau trafficking in and out of cells and to infer on the implications of this on the possible mechanisms of disease progression. 3) to see whether potential inhibitors of protein aggregation and propagation have an effect on what we observe within the cells we study. We will test several promising anti-aggregation and anti-propagation compounds that our collaborators provide.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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