Name of Fellow


Dr Timothy Couttas

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Myelin lipid breakdown affected by Apolipoprotein E genotype: implications for Alzheimer’s Disease pathogenesis

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 362,664

Start date of award


01/01/16

Total duration of award in years


5.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


alzheimer disease | apolipoprotein e | mass spectrometry | sphingolipids | biochemistry

Research Abstract


This project pieces together two important questions about Alzheimer’s Disease: (1) Why a naturally occurring variant of a gene called “APOE“ is the primary genetic risk for Alzheimer’s. (2) Why Alzheimer’s preferentially affects brain regions that lose a fatty substance called myelin, the electrical insulation of the brain. In doing so, we will understand more about what makes people more susceptible to Alzheimer’s and whether therapies to restore myelin could be effective against Alzheimer’s.

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