Principal Investigators

    F.Re, C.Almeida, TG.Ohm, W.Scheper



    Contact information of lead PI



    Title of project or programme

    NAB3: Development of a Novel Multicellular In Vitro Model of Alzheimer’s disease-like Blood-Brain Barrier

    Source of funding information


    Total sum awarded (Euro)

    € 812,488

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    A striking challenge in diagnosis and therapy of neurodegenerative diseases is the design of drugs capable of crossing the blood-brain barrier (BBB), a tightly regulated barrier that prevents the passage of drugs from the blood to the brain. In vitro cellular BBB models are available, but they mimic only healthy conditions without taking into account the BBB alterations associated with neurodegenerative diseases, like Alzheimer’s disease (AD). This project aims to develop and characterize a complex in vitro model of the BBB in AD condi- tions, built up with different cellular types combined with organotypic brain slices or neuronal cul- tures. This newly designed in vitro model will be realized thanks to the expertise and the multi- disciplinarity of the consortium in genetic engineering, physiology, neurobiology, neuroanatomy and biochemistry. The expected results will provide an innovative tool to i) obtain new infor- mation on the pathogenesis and pathophysiology of AD; ii) conduct more advanced early drug development and pre-clinical studies; and iii) devise new diagnostic or therapeutic strategies.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: France, Germany, Italy, JPND, Netherlands, Portugal
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF