Principal Investigators

    Chris Miller


    King's College London, Institute of Psychiatry

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Phosphorylation of kinesin light chain and calsyntenin-1/alcadein mediated axonal transport and processing of APP in Alzheimer’s disease

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 354,186

    Start date of award


    Total duration of award in years



    Research Abstract

    Neurons comprise cell bodies and wire-like processes called axons and dendrites that connect to each other at structures called synapses. There are up to 100 billion neurons and 100 trillion synapses in the human brain and this network enables the computing of information. Most neuronal proteins are made in the cell body and since axons and dendrites require proteins to function, they have to be transported from the cell body into and through the axons and dendrites to the synapse. This transport of protein “cargoes” involves “molecular motors” that run on “rails” and utilize a “fuel” called ATP. One key axonal motor is kinesin which moves along microtubule “rails”. As such, axonal transport is like a train journey with an engine (kinesin) using fuel to move cargoes along rails. We now know that axonal transport goes wrong in Alzheimer’s disease but it is not clear which aspect is defective. Like a train journey, there could be a problem with the engine, fuel supply, rails, signaling or even the cargoes themselves. We have discovered a new signaling pathway that has major implications for defective axonal transport in Alzheimer’s disease. This project is to study further, its role in Alzheimer’s disease.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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