Name of Fellow

    Malm Tarja



    Academy of Finland

    Contact information of fellow



    Title of project/programme

    Regulation of neuroinflammation in Alzheimer’s disease by non-coding RNAs

    Source of funding information

    Academy of Finland

    Total sum awarded (Euro)

    € 434,485

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Microglia | Alzheimer's disease | phagocytosis | non-coding RNA | beta-amyloid | TREM2 | exosome | lentivirus | nuclear receptor | adenoassociated virus | neuroinflammation

    Research Abstract

    Microglial dysfunction and inability to clear the toxic beta-amyloid accumulation is a significant contributor to neuronal death in Alzheimer’ s disease (AD). Prevention of the toxic cycle of neuroinflammation has been proposed to be an efficient treatment strategy for AD, yet targeting these pathways is difficult due to lack of knowledge in pathways regulating microglial functions at the level of gene transcription. This study aims at identifying the gene regulatory processes that take place specifically in microglia in healthy brain and during AD development by obtaining cutting-edge next generation sequencing data from non-coding RNA levels in microglia in situ in vivo by using state of art flow cytometric cell sorting techniques. We will elucidate whether non-coding RNA targeting could be used to modulate microglial functions for the disease benefit. This project is likely to reveal novel determinants of regulation of neuroinflammation in AD and yield novel therapeutic targets.

Types: Fellowships
Member States: Finland
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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