Principal Investigators

    M.Di Luca, C.Mulle, MR. Kreutz



    Contact information of lead PI



    Title of project or programme

    STAD: Synapse-to-nucleus communication in Alzheimer’s disease

    Source of funding information


    Total sum awarded (Euro)

    € 838,087

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Understanding how fast events at synapses are converted into long-lasting changes of neuronal acti- vity is a very important question in neuroscience. Several recent studies demonstrated that synapses and nuclei are connected by bidirectional communication routes that enable the efficient transfer of information and regulate the long-term structural changes of neuronal function. Moreover, several studies suggest that the disturbance of these communication routes is a common principle in many neurodegenerative diseases.

    Our primary hypothesis is that alterations in synapse-to-nucleus transport represent a main event asso- ciated with synaptic dysfunction in Alzheimer’s disease, which can be exacerbated by dysmetabo- lism. In particular, STAD will evaluate the properties of three synapse-to-nucleus messengers (Jacob, RNF10 and ICD) by testing whether interfering with their nuclear import can be beneficial or detri- mental with respect to the progression of Alzheimer’s disease.

    This research question will be performed through the development of innovative experimental mo- dels, in which synaptic failure, amyloid load and dysmetabolism may reveal the complexity of the human pathology. Overall, STAD will provide a characterization of the role played by the different synapse-to-nucleus pathways in Alzheimer’s disease and will generate novel animal models linking Alzheimer’s disease and dysmetabolism, thus disclosing a picture of the complex interplay of path- ways underlying Alzheimer’s disease pathogenesis.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: France, Germany, Italy, JPND
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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