Principal Investigators

    Dr. J.M. Dijk


    Academisch Medisch Centrum

    Contact information of lead PI



    Title of project or programme

    The INVEST study (Infusion VErsus STimulation), a cost-effectiveness analysis of the treatment of advanced Parkinson’s disease comparing Continuous Levodopa Infusion to the traditional standard treatment Deep Brain Stimulation

    Source of funding information


    Total sum awarded (Euro)

    € 400,000

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    OBJECTIVE(S)/RESEARCH QUESTION(S) To realize a cost-effective treatment strategy in advanced Parkinson’s disease (PD). Do additional costs of the frequently used Continuous Levodopa Infusion (CLI) lead to a sufficient increase in quality of life, compared to traditional standard treatment with Deep Brain Stimulation (DBS)?

    HYPOTHESIS CLI is no cost-effective therapy.

    STUDY DESIGN Prospective, randomized, open label multicenter trial, with two additional patient preference treatment arms (“patient preference randomized trial”).

    STUDY POPULATION(S)/DATASETS Patients with PD who, despite optimal pharmacological treatment, have severe response fluctuations, dyskinesias, painful dystonia, or bradykinesia. A total of 66 patients will be randomized, at least120 patients will be included in the patient preference arms.

    INTERVENTION For CLI treatment, a tube will be placed in the jejunum via a percutaneous endoscopic gastrostomy (PEG). The tube is connected to an external pump that delivers the Levodopa-gel.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Netherlands
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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