Dr Sam Buckberry
The role of the neuronal epigenome in natural brain ageing and the progression of Alzheimers disease
Alzheimer's disease & other dementias
methylation | epigenetics | neurogenetics | neurodegenerative disorders | genomics
Most cases of Alzheimer’s disease are sporadic or late onset, with only ~5% of cases being familial, suggesting a potential role for epigenetics. This project aims to profile the human brain epigenome throughout normal ageing and in Alzheimer’s disease so we can determine how disturbed epigenetic states may affect brain function. This research will provide new insights into the role of the epigenome in Alzheimer’s disease, enabling crucial advances in understanding its origins.