{"id":6847,"date":"2017-02-02T08:38:19","date_gmt":"2017-02-02T08:38:19","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6847"},"modified":"2017-02-02T08:38:19","modified_gmt":"2017-02-02T08:38:19","slug":"in-alzheimers-excess-tau-protein-damages-brains-gps","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/sv\/2017\/02\/in-alzheimers-excess-tau-protein-damages-brains-gps\/","title":{"rendered":"In Alzheimer\u2019s, Excess Tau Protein Damages Brain\u2019s GPS"},"content":{"rendered":"

Researchers have discovered that the spatial disorientation that leads to wandering in many Alzheimer\u2019s disease patients is caused by the accumulation of tau protein in navigational nerve cells in the brain. The findings, in mice, could lead to early diagnostic tests for Alzheimer\u2019s and highlight novel targets for treating this common and troubling symptom.<\/p>\n

The study was published online in the journal Neuron<\/em>.<\/p>\n

An estimated three out of five people with Alzheimer\u2019s disease wander and get lost, usually beginning in the early stages of the disease, leaving them vulnerable to injury. Researchers suspect that these problems originate in an area of the brain known as the entorhinal cortex (EC). The EC plays a key role in memory and navigation and is among the first brain structures affected by the buildup of neurofibrillary tangles that are largely composed of tau, a hallmark of Alzheimer\u2019s disease.<\/p>\n

The researchers focused their investigations on excitatory grid cells, a type of nerve cell in the EC that fires in response to movement through space, creating a grid-like internal map of a person\u2019s environment. The researchers made electrophysiological recordings of the grid cells of older mice\u2013including mice engineered to express tau in the EC (EC-tau mice) and normal controls\u2013as they navigated different environments. Spatial cognitive tasks revealed that the EC-tau mice performed significantly worse compared to the controls, suggesting that tau alters grid cell function and contributes to spatial learning and memory deficits.<\/p>\n

Detailed histopathological analysis of the mouse brains revealed that only the excitatory cells, but not the inhibitory cells, were killed or compromised by pathological tau, which probably resulted in the grid cells firing less.<\/p>\n

The findings raise the possibility that spatial disorientation could be treated by correcting this imbalance through transcranial stimulation, deep-brain stimulation, or light-based therapy.<\/p>\n

Paper: \u201cTau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer\u2019s Disease\u201d<\/a>
\nReprinted from materials provided by Columbia University Medical Center<\/a>. <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers have discovered that the spatial disorientation that leads to […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4991,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nIn Alzheimer\u2019s, Excess Tau Protein Damages Brain\u2019s GPS - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/02\/in-alzheimers-excess-tau-protein-damages-brains-gps\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In Alzheimer\u2019s, Excess Tau Protein Damages Brain\u2019s GPS - 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