The Gipuzkoa Alzheimer Project Study

The Gipuzkoa Alzheimer Project (PGA) is a longitudinal study on pre-clinical Alzheimer’s disease. This study aims to investigate the prevalence, clinical, cognitive and neuroimaging features and potential risk factors related to cardiovascular health and lifestyles for pre-clinical AD in asymptomatic (or very mildly symtopmatic, e.g. SCD) subjects from the community.

Follow-up Scheduled every 3 years for a minimum of 12 years. The first 3-year follow-up was completed in June 2015. The loss of subjects in the follow up was 9 %. 80% of people who donated cerebrospinal fluid at the baseline visit did the same in this follow-up visit. Second follow-up visit (6 yrs) to be started in April 2017.

Last update: 16/01/2017

Types Neurodegenerative disease-specific cohort
Participant Types At-risk diagnosis
Countries Spain
Genders Male and Female
Sample sizes 0 to 4,999
Ages 40 to 59|60 to 100
Brain related measures Mental health
Funtional rating Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular
Biological samples Blood|Urine
Genotyping
Brain imaging Magnetic resonance imaging (MRI)|Magnetic resonance spectroscopy (MRS)
Brain banking
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic
Health service utilisation
Institute names Fundación CITA-Alzheimer Fundazioa
Current Sample Sizes 0 to 4,999

age at recruitment 40-80
last updated
recruitment period May 11-Dec 12
estimated current sample size number value 230
cohort acronym GAP
start date May 11-Dec 12
pi Dr. Pablo Martinez-Lage
website http://www.cita-alzheimer.org/projects/gipuzkoa-alzheimer-project-basque-cohort
contact details Fundación CITA-Alzheimer Fundazioa
Pº Mikeletegi 71
20009 Donostia-San Sebastián
España
abstract  GAP/PGA is a longitudinal study on pre-clinical Alzheimer’s disease. 396 participants aged between 40-80yrs were recruited between May 2011 and December 2012.
funders  Fundacion Cita-Alzheimer Fundazioa
Basque Government
Gipuzkoa Local Government
Kutxa Fundazioa
contact email PI Email: [email protected]
contact phone number +34 (0) 943021792
estimated current sample size 0 to 4,999
sample sizes 300