{"id":13274,"date":"2018-04-03T11:09:48","date_gmt":"2018-04-03T11:09:48","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=13274"},"modified":"2018-04-03T11:09:48","modified_gmt":"2018-04-03T11:09:48","slug":"scientists-adapt-new-brain-disease-test-for-parkinsons-dementia-with-lewy-bodies","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/tr\/2018\/04\/scientists-adapt-new-brain-disease-test-for-parkinsons-dementia-with-lewy-bodies\/","title":{"rendered":"Scientists Adapt New Brain Disease Test for Parkinson\u2019s, Dementia with Lewy Bodies"},"content":{"rendered":"

Scientists developing a rapid, practical test for the early diagnosis of prion diseases have modified the assay to offer the possibility of improving early diagnosis of Parkinson\u2019s disease and dementia with Lewy bodies.<\/p>\n

The findings were published in Acta Neuropathologica Communications<\/em>.<\/p>\n

The group tested 60 cerebral spinal fluid samples, including 12 from people with Parkinson\u2019s disease, 17 from people with dementia with Lewy bodies, and 31 controls, including 16 of whom had Alzheimer\u2019s disease. The test correctly excluded all the 31 controls and diagnosed both Parkinson\u2019s disease and dementia with Lewy bodies with 93 percent accuracy.<\/p>\n

Importantly, test results were available within two days, compared to related assays that require up to 13 days. The group conducted the tests using Real-Time Quaking-Induced Conversion (RT-QuIC), an assay developed and refined over the past decade.<\/p>\n

Multiple neurological disorders, including Parkinson\u2019s disease and dementia with Lewy bodies, involve the abnormal clumping of a protein called alpha-synuclein into brain deposits called Lewy bodies. The pathological processes in these diseases resemble prion diseases in mammal brains. Like prion diseases, Parkinson\u2019s disease and dementia with Lewy bodies result in progressive deterioration of brain functions.<\/p>\n

The researchers continue to adapt the RT-QuIC assay to detect additional types of neurological diseases with greater accuracy using the least invasive patient sample possible\u2014whether that is blood, skin, nasal brushings, or other samples. The group also has trained many international colleagues to use and advance the test.<\/p>\n

Article:\u00a0\u201cRapid and ultra-sensitive quantitation of disease-associated \u03b1-synuclein seeds in brain and cerebrospinal fluid by \u03b1Syn RT-QuIC\u201d<\/a>\u00a0<\/strong>
\nReprinted from materials provided by NIH\/National Institute of Allergy and Infectious Diseases<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists developing a rapid, practical test for the early diagnosis […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4996,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-13274","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nScientists Adapt New Brain Disease Test for Parkinson\u2019s, Dementia with Lewy Bodies - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/it\/2018\/04\/scientists-adapt-new-brain-disease-test-for-parkinsons-dementia-with-lewy-bodies\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Adapt New Brain Disease Test for Parkinson\u2019s, Dementia with Lewy Bodies - 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