{"id":6799,"date":"2017-01-20T09:43:08","date_gmt":"2017-01-20T09:43:08","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6799"},"modified":"2017-01-20T09:43:08","modified_gmt":"2017-01-20T09:43:08","slug":"the-messenger-in-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/tr\/2017\/01\/the-messenger-in-huntingtons-disease\/","title":{"rendered":"The Messenger in Huntington\u2019s Disease"},"content":{"rendered":"<p>Newly published research has brought to light new information on the molecular mechanisms that cause Huntington\u2019s disease, and defines new pathways to therapy discovery. The results of the study are published in <em>The Journal of Clinical Investigation<\/em>.<\/p>\n<p>Huntington\u2019s disease is caused by the excessive repetition of a nucleotide triplet (CAG) in the Huntingtin gene. The number of CAG repetitions varies from person to person. Healthy individuals can have up to 36 repetitions. Nevertheless, as of 36 repetitions, Huntington\u2019s disease develops. The direct consequence of this excess of repetitions is the synthesis of a mutated protein\u2013different from what would be obtained without the additional CAG repetitions\u2013which has been considered the main cause of the disease for the past 20 years.<\/p>\n<p>\u201cWhat we have observed in our study is that the mutated fragment acting as a conveyor\u2013the so-called messenger RNA\u2013is key in the pathogenesis,\u201d says Dr. Eul\u00e0lia Mart\u00ed, one of the lead authors of the paper.\u00a0 \u201cThe research on this disease being done by most groups around the world seeking new therapeutic strategies focuses on trying to prevent expression of the mutated protein. Our work suggests that blocking the activity of messenger RNA (the \u2018conveyor\u2019), would be enough to revert the alterations associated with Huntington\u2019s disease. We hope this will contribute to improving the strategies in place to find a cure.\u201d<\/p>\n<p>Paper: <a href=\"https:\/\/www.jci.org\/articles\/view\/83185\">\u201cTargeting CAG repeat RNAs reduces Huntington\u2019s disease phenotype independently of huntingtin levels\u201d<\/a><br \/>\nReprinted from materials provided by the <a href=\"http:\/\/www.crg.eu\/en\/news\/messenger-huntingons-disease\">Centre for Genomic Regulation<\/a>. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Newly published research has brought to light new information on [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/tr\/2017\/01\/the-messenger-in-huntingtons-disease\/\">View Post<\/a>","protected":false},"author":3,"featured_media":4999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6799","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - 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