tTA-hLRRK2-WT-Rat

General Information

Rat: Sprague-Dawley

These rats express the tetracycline-controlled transactivator under a constitutive promoter (CAG-tTA) and the human LRRK2 gene tagged with HA and under the control of a tretracycline-responsive element (TRE)-fused mini-cytomegalovirus promoter. In this model, the human LRRK2 gene is expressed in the absence of tetracycline or its derivatives (e.g. Doxycycline).

Endogenous rat LRRK2 : yes

Corresponding human genotype: LRRK2 is the greatest known genetic contributor to Parkinson’s disease.

Mutated gene: hLRRK2

References: Zhou 2009

Transgene expression

  • The transgene is expressed in various tissues, including the cortex, brain stem and the cerebellum.

Neurodegeneration

  • Not reported

Dopamine Homeostasis

  • Not reported

Inclusions

  • Not reported

Motor Behaviours

  • 1.5-3 months: Motor performances of the transgenic animals appear normal on the accelerating rotarod.

Response to dopaminergic treatment

  • Non-applicable in the absence of motor impairment.

Non-motor Behaviours

  • Not reported

Electrophysiology

  • Not reported

Neuroinflammation

  • Not reported
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