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Title of project or programme
Wellcome Trust/MRC Strategic Award: Understanding Parkinson’s disease – lessons from biology
Principal Investigators of project/programme grant
| Title | Forname | Surname | Institution | Country |
| Professor | Nicolas | Wood | University College London | UK |
| Professor | John | Hardy | University College London | UK |
| Professor | Anthony | Schapira | University College London | UK |
Address of institution of lead PI
| Institution | Institute of Neurology, University College London |
| Street Address | The National Hospital University College London, Queen’s Square |
| City | London |
| Postcode | WC1N 3BG |
Country
- United Kingdom
Source of funding information
Medical Research Council
Total sum awarded (Euro)
6916055.43
Start date of award
01-03-2010
Total duration of award in months
60
The project/programme is most relevant to
- Parkinson’s disease
Keywords
Research abstract in English
In this ambitious proposal we have assembled a group of world-leading clinical and basic science researchers possessing complementary expertise to identify and tackle the causes of Parkinson’s Disease (PD). The overall goal will be a fuller understanding of the molecular pathogenesis of PD as well as improved clinical assessment of the disease prodrome. The main goals of the project are:
1. To undertake comprehensive genetic analysis of a large number of well characterised PD patients to identify rare variants and novel genes that cause and predispose to disease.
2. To perform state of the art molecular and biochemical characterisation of existing and novel PD-causing gene products and their pathways to delineate the regulation and function of these proteins.
3. To clinically dissect the prodrome of PD using a large series of at risk patients. The consortium brings together both established PD researchers and senior researchers from other disciplines whose expertise brings new skills to this programme.
This research should yield crucial new knowledge of the molecular pathways leading to neurodegeneration and shed insight into the causation of PD.
Lay Summary
Wellcome Trust/MRC Strategic Award: Understanding Parkinson’s disease – lessons from biology
Investments > €500k
United Kingdom
Parkinson’s disease & PD-related disorders
2011