Name of Fellow


Dr Kathryn Munro

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Protecting synaptic connectivity in Alzheimer's disease

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 389,111

Start date of award


01/01/16

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


neuroscience | synaptic plasticity | synapse formation | memory | alzheimer disease

Research Abstract


In Alzheimer’s disease, connections between neurons (synapses) are progressively damaged. The BACE inhibitor class of drugs entering Phase III clinical trials may slow the pace of neurodegeneration in patients with dementia. However, these drugs may simultaneously have negative effects on synapse function, learning and memory. This study will assess the effect of BACE inhibition on synapse properties and cognition and identify the contribution of key proteins affected by this treatment.

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