Name of Fellow


Dr Peng Lei

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Tau and APP interactions in Neurodegeneration

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 130,043

Start date of award


01/01/13

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


alzheimer disease | microtubule associated protein (map) | parkinson disease | iron transport | amyloid precursor protein

Research Abstract


Recently I co-discovered a novel relationship between the Alzheimer’s amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.

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