Name of Fellow


Solomon Alina

Institution


Funder


Academy of Finland

Contact information of fellow


Country


Finland

Title of project/programme


Fingerprinting the risk of dementia and likelihood of intervention response to facilitate prevention-related decision-making

Source of funding information


Academy of Finland

Total sum awarded (Euro)


€ 434,485

Start date of award


01/09/15

Total duration of award in years


5.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Dementia | Alzheimer disease | prevention | clinical trials | epidemiology | biomarkers | computer-based risk profiling

Research Abstract


Dementia and Alzheimer disease prevention is a major public health priority. This project focuses on formulating tools for identifying high-risk individuals who may benefit from preventive interventions. Novel computer-based methods (Disease State Index, Disease State Fingerprint) will be used for analysis and visualization of a broad range of dementia-related factors and biomarkers. Specific aims include: 1) Risk index estimating an individual’s risk of cognitive impairment/dementia; 2) Intervention response index estimating an individual’s likelihood to respond to preventive interventions; 3) Planning a protocol for prevention-related decision-making. The project combines several large observational population-based studies (FINRISK, CAIDE, Vantaa 85+) and prevention trials (FINGER, MAPT, LipiDiDiet). It can produce comprehensive profiling tools that can facilitate personalization of preventive strategies in order to make them more effective.

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