Principal Investigators


Prof Paul Gleeson

Institution


University of Melbourne

Contact information of lead PI


Country


Australia

Title of project or programme


Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 470,771

Start date of award


01/01/2015

Total duration of award in years


3

Keywords


Research Abstract


The development of Alzheimer’s disease results from the generation of toxic peptides by the cleavage of a membrane protein by an enzyme called BACE. A key feature of which regulates the generation of toxic peptides involves the movement of BACE between compartments in the cell by a process known as membrane transport. Our recent work has identified the itinerary of BACE in the cell. The studies here will reveal the molecular machinery of the BACE pathway in neurons. This fundamental informati

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