Principal Investigators

    Prof Paul Gleeson


    University of Melbourne

    Contact information of lead PI



    Title of project or programme

    Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and the production of Abeta amyloid peptides

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 470,771

    Start date of award


    Total duration of award in years



    Research Abstract

    The development of Alzheimer’s disease results from the generation of toxic peptides by the cleavage of a membrane protein by an enzyme called BACE. A key feature of which regulates the generation of toxic peptides involves the movement of BACE between compartments in the cell by a process known as membrane transport. Our recent work has identified the itinerary of BACE in the cell. The studies here will reveal the molecular machinery of the BACE pathway in neurons. This fundamental informati

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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