Name of resource
BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC
Name of Principal Investigator
| Title | Dr/Dr |
| First name | |
| Last name | Pereira/Rego |
Address of institution where award is held
| Institution | Center for Neuroscience and Cell Biology (CNC) – Univ Coimbra |
| Street Address | R. Larga, 6 |
| City | Coimbra |
| Postcode | 3004-517 |
Country
Portugal
Website
http://www.cnbc.pt/
Contact email
Summary
1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
Alzheimer’s disease and other dementias Huntington’s disease
1b. The resource holds:
Animals
2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
2b. Procedures and rules for access
Apply to PI or co-ordinator at resource Access through collaboration with PI only Applicant needs to provide separate external ethics approval Other requirements exist National access International access Other requirements exist
3a. Does the resource develop animal models for external groups
1
3b. Types of models provided
Not applicable
4a This activity is supported as:
Not applicable
4b. The supplied material deposited in a central repository
1
5a Disease models available
| Disease | Species | Available to external user (Y/N) | Full phenotypic character (Y/N or partial) | Phenotypes | Genotypes or other subtypes |
| AD | N | Y | Cognitive deficits, senile plaques, neurofibrillary tangles, synaptic loss in cerebral cortex and hippocampus | 3xTg-AD (human mutant APP, PS1, tau)- background C57BL x 129sv | Mouse |
| YAC mouse model of HD expressing full-length human mutant huntingtin with 128 glutamines (YAC128, lines HD55 and HD53) | HD | Mouse | Y | Y | Hyperkinetic phenotype first manifested, followed by progressive motor deficits and age-dependent striatal neurodegeneration |
7a. Maintenance of the resource is dependent on continued funding
2
7b. End date of current funding period
2013
7c. Expected lifespan of the resource (in years)
10
7d. Other plans affecting future use
In one year more space available for production of new mice models colonies.
In three years probably a new facility.