Name of resource

BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC

Name of Principal Investigator
First name
Last namePereira/Rego
Address of institution where award is held
InstitutionCenter for Neuroscience and Cell Biology (CNC) – Univ Coimbra
Street AddressR. Larga, 6
  • Portugal
  • Website

    Contact email
    1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
  • Alzheimer’s disease and other dementias
  • Huntington’s disease
  • 1b. The resource holds:
  • Animals
  • 2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
    2b. Procedures and rules for access
  • Apply to PI or co-ordinator at resource
  • Access through collaboration with PI only
  • Applicant needs to provide separate external ethics approval
  • Other requirements exist
  • National access
  • International access
  • Other requirements exist
  • 3a. Does the resource develop animal models for external groups


    3b. Types of models provided
  • Not applicable
  • 4a This activity is supported as:
  • Not applicable
  • 4b. The supplied material deposited in a central repository


    5a Disease models available
    DiseaseSpeciesAvailable to external user (Y/N)Full phenotypic character (Y/N or partial)PhenotypesGenotypes or other subtypes
    ADNYCognitive deficits, senile plaques, neurofibrillary tangles, synaptic loss in cerebral cortex and hippocampus3xTg-AD (human mutant APP, PS1, tau)- background C57BL x 129svMouse
    YAC mouse model of HD expressing full-length human mutant huntingtin with 128 glutamines (YAC128, lines HD55 and HD53)HDMouseYYHyperkinetic phenotype first manifested, followed by progressive motor deficits and age-dependent striatal neurodegeneration
    7a. Maintenance of the resource is dependent on continued funding


    7b. End date of current funding period


    7c. Expected lifespan of the resource (in years)


    7d. Other plans affecting future use

    In one year more space available for production of new mice models colonies.

    In three years probably a new facility.

      Types: Experimental Models
      Member States: Portugal
      Diseases: Alzheimer's disease & other dementias, Huntington's disease
      Years: 2011
      Database Categories: N/A
      Database Tags: N/A

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