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Title of project or programme
Neuro-immune modelling
Principal Investigators of project/programme grant
| Title | Forname | Surname | Institution | Country |
| Professor | Jean | Manson | University of Edinburgh | United Kingdom |
Address of institution of lead PI
| Institution | The Roslin Institute, University of Edinburgh |
| Street Address | Easter Bush, Midlothian |
| City | Edinburgh, Scotland |
| Postcode | EH25 9RG |
Country
United Kingdom
Source of funding information
Biotechnology and Biological Sciences Research Council
Total sum awarded (Euro)
1328945
Start date of award
01-08-2008
Total duration of award in months
36
The project/programme is most relevant to
- Prion disease
Keywords
Research abstract in English
The spread of TSE infection within the body of an animal often starts with transport from the site of invasion to the lymphoreticular system (LRS) and then to the central nervous system (CNS). We wish to study this process to identify the important factors that affect host susceptibility and to define control points at which neuroinvasion might be arrested so that clinical disease does not occur. The objectives of this theme are: To determine the mechanisms of TSE agent delivery to the lymphoid system. To determine crucial sites of TSE agent accumulation and/or replication in lymphoid tissues. To determine the mechanisms of neuroinvasion (how TSE agents spread to peripheral nerves). To determine the role of macrophages in TSE pathogenesis. To determine the influence of host age on TSE agent neuroinvasion. To determine the influence of inflammation on TSE pathogenesis.
Lay summary
Neuro-immune modelling
Investments > €500k
United Kingdom
Prion disease
2011