Nature of TSE infection and Routes of Transmission

Title of project or programme
Nature of TSE infection and Routes of Transmission
Principal Investigators of project/programme grant

Address of institution of lead PI

Country
United Kingdom
Source of funding information
Biotechnology and Biological Sciences Research Council
Total sum awarded (Euro)
2462782
Start date of award
01-08-2008
Total duration of award in months
36
The project/programme is most relevant to

• Prion disease

Keywords

Research abstract in English
We aim to study the biochemical and biophysical nature of different strains of agent and their modes of transfer from animal to animal for the development of specific disease control in combination with efficient health and environmental protection measures. The refinement of diagnostic methods and genetic programmes will be used to eradicate novel TSE agents and provide models for risk reduction in other diseases. We will follow the agent in its route into the host and study the cellular, molecular and genetic mechanisms that enhance or prevent efficient transmission. The objectives of this theme are: To define TSE strains. Understand the TSE infectious agent and diagnosing disease. Define routes of transmission between animals. Understand genetic control of susceptibility/resistance. To define the role of PrP gene regulation in TSE disease. Investigate therapeutic intervention.
Lay summary

Nature of TSE infection and Routes of Transmission

Investments > €500k
United Kingdom
Prion disease
2011