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Targeting the kynurenine pathway in Alzheimers disease

Targeting the kynurenine pathway in Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimers Disease

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Pathway discovery, validation and compound identification for Alzheimers disease

Pathway discovery, validation and compound identification for Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Phase 1 safety trial for CT1812, a novel small molecule therapeutic targeting a synaptic receptor for Abeta oligomers

Phase 1 safety trial for CT1812, a novel small molecule therapeutic targeting a synaptic receptor for Abeta oligomers Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Exercise and Intensive Vascular Risk Reduction in Preventing Dementia

Exercise and Intensive Vascular Risk Reduction in Preventing Dementia Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Estimating Long-Term Disease Trajectories from Short-Term Data

Estimating Long-Term Disease Trajectories from Short-Term Data Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

A biomarker-driven trial of angiotensin receptor blockers for prodromal Alzheimer

A biomarker-driven trial of angiotensin receptor blockers for prodromal Alzheimer Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Poor Sleep Altered Circadian Rhythms and Alzheimers Disease

Poor Sleep Altered Circadian Rhythms and Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Neuropathology for disrupted multiscale activity control in Alzheimers disease

Neuropathology for disrupted multiscale activity control in Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Nighttime Agitation and Restless Legs Syndrome in People with Alzheimers Disease

Nighttime Agitation and Restless Legs Syndrome in People with Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

A sleep electroencephalography biomarker predicting Alzheimers disease pathology

A sleep electroencephalography biomarker predicting Alzheimers disease pathology Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Association of Disturbed Sleep with Cognitive Performance in the Baltimore Longitudinal Study of Aging

Association of Disturbed Sleep with Cognitive Performance in the Baltimore Longitudinal Study of Aging Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Apnea and local sleep: Mechanism and intervention in preclinical Alzheimers

Apnea and local sleep: Mechanism and intervention in preclinical Alzheimers Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Alzheimer Disease Genetic Architecture in African Americans

Alzheimer Disease Genetic Architecture in African Americans Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Prediction of Psychosis in Alzheimer Disease

Prediction of Psychosis in Alzheimer Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

APOEomic: Searching for APOE interacting risk factors using omics data

APOEomic: Searching for APOE interacting risk factors using omics data Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems

ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Replication and Extension of ADSP Discoveries in African-Americans

Replication and Extension of ADSP Discoveries in African-Americans Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

AD Gene Discovery: Exome Chip, New Endophenotypes & Functional Studies in CHARGE

AD Gene Discovery: Exome Chip, New Endophenotypes & Functional Studies in CHARGE Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Deep Resequencing of Candidate Gene Regions in Late-onset Alzheimers Disease

Deep Resequencing of Candidate Gene Regions in Late-onset Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Genetic architecture of memory and executive functioning in Alzheimers disease

Genetic architecture of memory and executive functioning in Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Alzheimer Disease Genetic Architecture in African Americans

Alzheimer Disease Genetic Architecture in African Americans Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Search for the Alzheimers Genes

Search for the Alzheimers Genes Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

USING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITS

USING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITS Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Search for the Alzheimers Genes

Search for the Alzheimers Genes Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Gene Expression Biomarkers for Early Identification of Mild Cognitive Impairment: A Twin Study

Gene Expression Biomarkers for Early Identification of Mild Cognitive Impairment: A Twin Study Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Genetic Epidemiology of Cerebrovascular Factors in Alzheimers Disease

Genetic Epidemiology of Cerebrovascular Factors in Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Modeling Axonal Density and Inflammation-Associated Cellularity in Alzheimers Disease Using Hybrid Diffusion Imaging

Modeling Axonal Density and Inflammation-Associated Cellularity in Alzheimers Disease Using Hybrid Diffusion Imaging Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

CSF, MRI, and PET biomarkers of neuroinflammation in Alzheimers disease

CSF, MRI, and PET biomarkers of neuroinflammation in Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Protein variants as blood based biomarkers for diagnosing and staging AD

Protein variants as blood based biomarkers for diagnosing and staging AD Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Commercialization of a serum diagnostic for detection of Alzheimers Disease

Commercialization of a serum diagnostic for detection of Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Biomarkers of Alzheimers Disease in Adults with Down Syndrome

Biomarkers of Alzheimers Disease in Adults with Down Syndrome Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Imaging and genetic biomarkers for Alzheimers disease

Imaging and genetic biomarkers for Alzheimers disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Blood-based diagnostics for Alzheimers Disease

Blood-based diagnostics for Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Wisconsin Registry for Alzheimers Prevention: Sex Differences in DNA Methylation

Wisconsin Registry for Alzheimers Prevention: Sex Differences in DNA Methylation Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Analyzing Large-Scale Neuroimaging Data in Alzheimers Disease

Analyzing Large-Scale Neuroimaging Data in Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Nanowire Sensor Array-based Assay for Early Diagnosis of Alzheimers Disease

Nanowire Sensor Array-based Assay for Early Diagnosis of Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Blood-based diagnostics for Alzheimers Disease

Blood-based diagnostics for Alzheimers Disease Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study

Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Evolution of memory related fMRI activation over the course of MCI and AD

Evolution of memory related fMRI activation over the course of MCI and AD Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Optimized Arterial Spin Labeling MRI in Mild Cognitive Impairment

Optimized Arterial Spin Labeling MRI in Mild Cognitive Impairment Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

The Pharmacological Enhancement of Sleep for Memory Improvement

The Pharmacological Enhancement of Sleep for Memory Improvement Investments > €500k United States of America Alzheimer’s disease & other dementias 2016

Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)

Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS) Investments > €500k United States of America Alzheimer’s disease & other dementias 2016