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Harnessing the Ubiquitin-Proteasome System in the Brain: Implications for Dementia Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK Northern Ireland Network Centre Grant Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK Cambridge Network Centre Grant Investments < €500k United Kingdom 2016    

The role of TMEM106B and CHMP2B in neuronal lysosomal trafficking in frontotemporal dementia Investments < €500k United Kingdom 2016    

Imaging cerebral vascular alterations and their modulation in experimental models: a translational approach Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK Imperial College London Network Centre Grant Investments < €500k United Kingdom 2016    

Cellular modelling of C9orf72 di-peptide repeat proteins Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK South West Network Centre – Year 2 Investments < €500k United Kingdom 2016    

Validation of an O-GlcNAcase inhibitor as a novel therapeutic agent against Alzheimer pathology Investments < €500k United Kingdom 2016    

Ultra-high field MRI in early Alzheimer’s disease: characterising iron deposition Investments < €500k United Kingdom 2016    

Ensuring High Quality DNA and RNA isolation from the Brains for Dementia Research (BDR) Resource using the Agilent 2200 TapeStation Nucleic Acid System. Investments < €500k United Kingdom 2016    

2nd Neurodegeneration Conference Investments < €500k United Kingdom 2016    

Functional deficits in a novel murine model of frontotemporal lobar degeneration Investments < €500k United Kingdom 2016    

Automated subcortical brain segmentation using multispectral MRI for improved AD diagnosis and disease tracking Investments < €500k United Kingdom 2016    

Altered Heparan Sulfate in Ageing and Dementia: a Potential Axis for Dysregulation of BACE-1 in Alzheimers Disease Investments < €500k United Kingdom 2016    

Using genetic variability in whole transcriptome expression in the hippocampus and temporal cortex to understand the pathogenesis of Alzheimer’s disease Investments < €500k United Kingdom 2016    

Investigating the role of kinesin motor proteins in a human neuronal cell model of Alzheimer’s Disease: a new drug discovery target? Investments < €500k United Kingdom 2016    

A biological resource for metagenomic studies of dementia Investments < €500k United Kingdom 2016    

Characterisation of a novel in vivo model of human tauopathy Investments < €500k United Kingdom 2016    

Investigation into the impact of systemic inflammation due to infection on microglial phenotype and its contribution to Alzheimer’s disease neuropathology Investments < €500k United Kingdom 2016    

Enabling high-throughput genomic approaches in Alzheimer’s disease. Investments < €500k United Kingdom 2016    

ALS disease models and therapeutic drug screen Investments < €500k United Kingdom 2016    

Characterisation of enteric nervous system function of the intestine in Alzheimer’s disease Investments < €500k United Kingdom 2016    

NeuroTraffic: Orientated neuronal networks for investigating mechanisms of tau propagation Investments < €500k United Kingdom 2016    

Hippocampal sclerosis – a poorly understood cause of dementia among the older old Investments < €500k United Kingdom 2016    

High-throughput and high-resolution digital slide scanner Nanozoomer-XR for studies in dementia Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK Manchester and North West Network Centre Grant Investments < €500k United Kingdom 2016    

Evaluating the relationship between ischaemia and neurodegeneration in post-mortem brain tissue Investments < €500k United Kingdom 2016    

THE ROLE OF ASTROCYTES IN TAU-RELATED NEURONAL CELL DEATH Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK Yorkshire Network Centre Grant Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK University College London Network Centre Grant Investments < €500k United Kingdom 2016    

O-GlcNAc as a strategy for the treatment of tauopathies Investments < €500k United Kingdom 2016    

Alzheimer’s Research UK King’s College London Network Centre Grant Investments < €500k United Kingdom 2016    

Identifications of druggable pathways that influence tau toxicity Investments < €500k United Kingdom 2016    

PSK kinases and tau pathology in Alzheimer’s disease Investments < €500k United Kingdom 2016    

Evaluation of tau aggregation detected by novel tau tracer, [18F]T807 PET in mild cognitive impairment subjects: a preliminary collaborative PET study. Investments < €500k United Kingdom 2016    

The role of TREM2 in neurodegeneration Investments < €500k United Kingdom 2016    

Investigating the effect of ApoE genotype on synaptic dysfunction using sporadic Alzheimer’s disease patient iPSC-derived cells Investments < €500k United Kingdom 2016    

Testing a new diagnostic tool for Alzheimer’s disease and Dementia with Lewy Bodies Investments < €500k United Kingdom 2016    

Fractalkine agonists to treat neurodegenerative disease Investments < €500k United Kingdom 2016    

Development of small molecule Usp8 inhibitors as therapeutics in Lewy body dementia Investments < €500k United Kingdom 2016    

Neurovascular dysfunction in Alzheimer’s disease: the search for early biomarkers Investments < €500k United Kingdom 2016    

Determining the role of lysosomal Ca2+ signalling in the pathogenesis of Alzheimer’s disease Investments < €500k United Kingdom 2016    

Emergence of cognitive impairment in an Alzheimer’s Disease mouse model: the role of NMDA receptor currents. Investments < €500k United Kingdom 2016    

Convergence of Abeta and tau pathogenic mechanisms on axonal transport Investments < €500k United Kingdom 2016    

Identification of unfolded protein response, apoptosis and autophagy markers in human AD Investments < €500k United Kingdom 2016    

Understanding Alzheimer’s disease using mouse models of Down syndrome Investments < €500k United Kingdom 2016    

CARASIL – a window into Alzheimer’s disease? Investments < €500k United Kingdom 2016    

A cell surface, lipid raft-based signalling complex links amyloid-beta to tau via Fyn Investments < €500k United Kingdom 2016    

Complement and microglial activation in mouse models of dementia Investments < €500k United Kingdom 2016