Export as PDF
Cohort Acronym

Cohort type
Rare neurodegenerative condition

Alzheimer's disease, Lewy body disease

Participant type
Condition diagnosed

Recruitment Period 2013 
Sample size at start or planned sample size if still recruiting 80  
Estimated Current Sample Size  
Age at Recruitment >60   
Gender Male and Female 

The AMPLE study has been set up to investigate differences and outcomes in those with Lewy body dementia with and without concurrent Alzheimer’s disease/pathology. The principle aim of AMPLE is to undertake amyloid PET imaging in Lewy Body Dementia (LBD) and Alzheimer’s disease (AD) of 80 participants over the age of 60 and investigate the distribution of amyloid burden in LBD relative to AD and controls at baseline. A further aim is to determine the relationship between amyloid levels at baseline, clinical features of the disease, other imaging changes and subsequent clinical course in follow up.

Primary analysis would divide LBD patients into high and low amyloid burden with participants then compared on clinical features with AD-like symptoms and cognitive profiles. Follow up will be completed annually through surveys and clinical examinations.

Last update – 01/02/2017

Country United Kingdom 
Contact details
Institution name Newcastle University 
Principal Investiator (PI) Professor John O'Brien 
Contact phone number +44 (0) 191 208 1322 
Address Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL 
Funders (Core support) NIHR Newcastle Biomedical Research Unit|Avid 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health
Funtional rating: Individual physiological, Individual psychological
Anthropometric: N/A
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood, Cerebral spinal fluid (CSF)
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: N/A
Lifestyle: Alcohol, Smoking
Socio-economic: Education
Health service utilisation: N/A
Export as PDF