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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Other NDs not listed, Vascular dementia

Participant type
No diagnosis

Recruitment Period 2011 
Sample size at start or planned sample size if still recruiting 19,114  
Estimated Current Sample Size  
Age at Recruitment > 65   
Gender Male and Female 

ASPREE is a double-blind, randomized, placebo-controlled primary prevention trial designed to assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy participants aged 70 years and above except for Hispanic and African American minority groups in the U.S. where the minimum age of entry is 65 years.

The primary objective is to determine whether low-dose aspirin prolongs life, or life free of dementia, or life free of significant, persistent physical disability in the healthy elderly. Secondary objectives relate to the effects of low-dose aspirin on the key outcome areas of death, cardiovascular disease, dementia and cognitive decline, cancer, physical disability, depression and major bleeding episodes. Variables were collected annually through visits and for the purposes of retention telephone calls were scheduled at set points through the 7 years.

Country Australia, USA 
Contact details
Institution name Monash University 
Principal Investiator (PI) Professor Anne Murray, Professor John McNeil and Ms Brenda Kirpach 
Contact phone number Tel: 612-873-6905 
Address USA:
ASPREE Project Manager, Brenda Kirpach
Berman Center for Outcomes & Clinical Research
701 Park Ave, Suite PPC4.440
Minneapolis, MN 55415

ASPREE National Co-ordinating and Clinical Trial Centre,
Ground Floor, Burnet Building
89 Commercial Road, Melbourne 3004 
Funders (Core support) USA and Australian Government 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood, Urine
Genotyping: N/A
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Martial status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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