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Cohort Acronym
rpAD Study

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease

Participant type
Condition diagnosed

Recruitment Period 2008 - Present 
Sample size at start or planned sample size if still recruiting  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 70   
Gender Male and Female 

The rpAD study is a longitudinal study, which recruits patients from the entire federal territory. In addition, patients from the Clinical Dementia Centre are recruited at the Neurological and Psychiatric Clinic of the University Medical Center of G’ttingen, with these usually classical clinical forms being internal controls. The aim of the study is to characterize the biological factors and parameters that define the disease progression in AD.

After the patient is informed and consent is given, the inclusion examination is carried out. It includes a detailed history and anamnesis as well as a physical examination, which includes an in-depth examination of the neurological status. A neuropsychological test for cognitive testing is performed using the CERAD-plus test battery. Furthermore, the GDS score is obtained, which allows an assessment of the severity of the cognitive deficits by means of a 7-stage classification. The ADL score is used to assess the activities of daily life (Lawton and Brody 1969).

Six months after the initial examination, a telephone follow-up is carried out. Further investigations are carried out on an annual basis and correspond to the initial examination.

Last Update 21/09/2017

Country Germany 
Contact details
Institution name University Medical School, Department of Neurology, G'ttingen 
Principal Investiator (PI) Professor Inga Zerr 
Contact email E-mail: [email protected]  
Contact phone number Phone: +49 (0) 551/39 66 36 
Address University Medical School
Department of Neurology
Robert Kochstrasse
40 37075
Funders (Core support) Kompetenznetz Degenerative Demenzen -KNDD by BMBF 

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Weight
Physical: Cardiovascular
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available
Genotyping: Gene screening
Brain imaging: Electroencephalogram (EEG), Magnetic resonance imaging (MRI), Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: N/A
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