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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Mild cognitive impairment (MCI)

Participant type
No diagnosis

Recruitment Period 2003-06 
Sample size at start or planned sample size if still recruiting 6734  
Estimated Current Sample Size 5,000 to 9,999 
Age at Recruitment 35-75   
Gender Male and Female 

The major goals of this prospective cohort study of a randomly selected community sample are to: establish the prevalence and genetic, metabolic and environmental determinants of psychiatric disorders, cardiovascular risk factors (CVRF) and cardiovascular diseases (CVD) in the general population of the city of Lausanne; assess the mechanisms of the association between psychiatric disorders and CVRF / CVD.
Additional scientific questions focus on:

  • the identification of risk factors for the incidence and course of CVRF and psychiatric disorders;
    the identification of risk factors for cognitive impairment;
  • the testing of novel biological marker candidates and the incidence or course of CVRF/CVD or psychiatric disorders;
  • the testing of associations between brain anatomy patterns and CVRF and psychiatric disorders.

Last update: 19/12/2016

Country Switzerland 
Contact details
Institution name University Hospital Of Lausanne (CHUV) 
Principal Investiator (PI) Professor Martin Preisig (psychiatric part), Professor Gerard Waeber and Professor Peter Vollenweider (physical part) 
Contact email [email protected] 
Contact phone number +44 41213 147361 
Address CoLaus¦PsyCoLaus
Rue du Bugnon 19
CH-1011 Lausanne 
Funders (Core support) GlaxoSmithKline (baseline investigation)
Swiss National Science Foundation (baseline and follow-up investigations) 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Respiratory
Biological samples: Blood, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Income and finances, Informal support, Marital status
Health service utilisation: Formal health and social care service utilisation including private care
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