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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Huntington's disease, Lewy body disease, Mild cognitive impairment (MCI), Motor neurone disease, Other NDs not listed, Parkinson's disease, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA), Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
Condition diagnosed

Recruitment Period Jun-02 
Sample size at start or planned sample size if still recruiting 2,097  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 17-80   
Gender Male and Female 

A family-based cohort study that is embedded in the Genetic Research in Isolated Populations (GRIP) program in the South West of the Netherlands. The aim of this program was to identify genetic risk factors in the development of complex disorders. For the ERF study, 22 families that had at least five children baptized in the community church between 1850-1900 were identified with the help of genealogical records. All living descendants of these couples and their spouses were invited to take part in the study. Data collection started in June 2002 and was finished in February 2005 (n=2065).

Country Netherlands 
Contact details
Institution name Erasmus Medical Center 
Principal Investiator (PI) Dr. Cornelia van Duijn and Dr Aaron Issacs 
Contact email [email protected] 
Contact phone number +31 (0) 10 70 43394 or +31 (0) 10 70 38194 
Address Department of Epidemiology
Erasmus Medical Center
PO Box 2040
3000 CA Rotterdam
the Netherlands 
Funders (Core support) European Commission, European Community’s Seventh Framework Programme 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: Electroencephalogram (EEG), Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Income and finances, Informal support, Martial status, Occupation and employment, Unpaid care
Health service utilisation: N/A
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