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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Parkinson's disease

Participant type
No diagnosis

Recruitment Period 2006-2011 
Sample size at start or planned sample size if still recruiting 23960  
Estimated Current Sample Size  
Age at Recruitment >18   
Gender Male and Female 

The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas of current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland.

Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17. This profile also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 1500 GS participants are being invited for scanning.

Last Update 21/09/2017

Country United Kingdom 
Contact details
Institution name Universities of Edinburgh, Aberdeen, Dundee and Glasgow and NHS Scotland 
Principal Investiator (PI) Professor David Porteous 
Contact email [email protected] PI Email: [email protected] 
Contact phone number +44 (0) 1316511040 
Address Medical Genetics Section,
University of Edinburgh,
Western General Hospital,
Crewe Road South,
EH4 2XU 
Funders (Core support) Scottish Government Health Directorates 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: N/A
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
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