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Cohort Acronym

Cohort type
General population-based cohort


Participant type
No diagnosis

Recruitment Period 1998-2003 
Sample size at start or planned sample size if still recruiting 3225  
Estimated Current Sample Size 1 to 4,999 
Age at Recruitment 59-73   
Gender Male and Female 

The Hertfordshire Cohort Study comprises a nationally unique study of 3000 men and women born during the period 1931-1939 and still resident in the English county of Hertfordshire. Information available on these individuals includes birthweight (recorded by the attending midwife), weight at age one year (recorded by a health visitor), the method of infant feeding, and details of childhood illnesses up to age five years. Follow-up of individuals began in 1990 and medical and social histories have been ascertained, as well as detailed anthropometry, blood pressure, glucose tolerance, fasting serum cholesterol and triglycerides, bone density and physical performance. DNA on all participants has been collected and is stored in the MRC Lifecourse Epidemiology Unit, University of Southampton, UK.

The entire cohort is being followed up through primary care and hospital records for clinical outcomes including incident coronary heart disease, cerebrovascular disease, chronic airflow obstruction and fracture. The cohort members are flagged with NHS Digital for notification of deaths.

HCS is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK’s longitudinal studies.

Last update: 31/01/2017

Country United Kingdom 
Contact details
Institution name University of Southampton 
Principal Investiator (PI) Professor Cyrus Cooper 
Contact email [email protected] 
Contact phone number +44 (0) 23 8077 7624 
Address University of Southampton
Southampton General Hospital
SO16 6YD 
Funders (Core support) Medical Research Council 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological
Anthropometric: Blood pressure, Height, Waist circumference, Weight
Physical: Cardiovascular, Musculoskeletal, Respiratory
Biological samples: Blood, Other, Urine
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Informal support, Marital status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
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